Endocrine Abstracts

A growing body of preclinical and clinical evidence has demonstrated that mineralocorticoids, especially aldosterone, are intimately involved in the development of target organ injury in all major target organs of hypertensive disease, and that pharmacological inhibition of mineralocorticoids, or adrenalectomy markedly reduces myocardial injury, stroke and renal vascular disease. Animal studies demonstrated that aldosterone/salt treatment induces inflammatory remodeling of cor...

Introdution: Erdheim-Chester disease is a rare multisystemic form of Non-langerhans cell histiocytosis CD67 positive, with approximately 550 published cases. Papillary carcinoma is the most common thyroid cancer with BRAF V600E the most common mutation. Both diseases may be associated to BRAF V600E mutation. If Erdheim- Chester disease is positive to this mutation on histiocytes, a specific pharmacolgical treatment is available, (vemurafenib), with better results.<p class=...